Effects of deletions of mbtH-like genes on clorobiocin biosynthesis in Streptomyces coelicolor

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Effects of deletions of mbtH-like genes on clorobiocin biosynthesis in Streptomyces coelicolor.

In the biosynthetic gene cluster of the aminocoumarin antibiotic clorobiocin, the small ORF cloY encodes a 71 aa protein which shows significant sequence similarity to mbtH from the mycobactin biosynthetic gene cluster of Mycobacterium tuberculosis. mbtH-like genes are frequently found in the biosynthetic gene clusters of peptide antibiotics and siderophores, but their function has remained eni...

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ژورنال

عنوان ژورنال: Microbiology

سال: 2007

ISSN: 1350-0872,1465-2080

DOI: 10.1099/mic.0.2006/002998-0